Application of nano-graphene oxide as nontoxic disinfectant against alpha and betacoronaviruses
Hee-Chun Chung 1, Van Giap Nguyen 2, Cheong Ung Kim 3, Hai-Quynh Do 1 4, Bong Kyun Park 1, Yong Ho Park 3, Dae-Sub Song 5, Aeri Kong 6, Jae-Chul Ryu 7, Kyung-Sun Kang 7
Abstract
New viruses are continuously emerging and recently there have been many great concerns on severe acute respiratory syndrome coronavirus (SARS-CoV-2). Nanographene oxide (nanoGO) has received much attention and is widely investigated to be utilised in therapy for infectious diseases by viruses. Thus, antiviral activity of nanoGO was evaluated using the porcine epidemic diarrhoea virus (PEDV), bovine coronavirus (BCoV), and SARS-CoV-2, which are all Alpha- and Beta-coronavirus. In a virus inhibition assay, the three viruses were inhibited by nanoGO in a dose-dependent manner, including attempts in the presence of high serum solution which partially mimicked biological fluid.
